HUBUNGAN PROTEINURIA DAN ANGKA LEUKOSIT PADA IBU HAMIL DENGAN PREEKLAMPSIA BERAT DI RSUD PANEMBAHAN SENOPATI

Rismaya Salsabila Putri; Aji Bagus Widyantara; Lisa Wahyuningrum; Rismaya Salsabila Putri; Aji Bagus Widyantara; Lisa Wahyuningrum

Rismaya Salsabila Putri Universitas `Aisyiyah Yogyakarta
Aji Bagus Widyantara Universitas `Aisyiyah Yogyakarta
Lisa Wahyuningrum Universitas `Aisyiyah Yogyakarta

Keywords

Severe Preeclampsia, Proteinuria, Leukocyte Count

Abstract

Abstract: Maternal mortality remains a significant public health concern. Based on data from the 2020 Population Census Survey, maternal deaths accounted for approximately 33% of total mortality, with preeclampsia and eclampsia identified as the leading causes. This study was conducted to describe and analyze the relationship between the degree of proteinuria and leukocyte count in pregnant women diagnosed with severe preeclampsia at Panembahan Senopati Regional Hospital.A quantitative descriptive study with a cross-sectional design was employed. The sampling technique used was total sampling, including all medical records of urine protein and blood leukocyte examinations from pregnant women with severe preeclampsia who met the inclusion and exclusion criteria during the second semester of 2024. A total of 36 respondents were included in this study. Data were analyzed using descriptive statistics to illustrate the distribution of proteinuria levels and leukocyte counts. Furthermore, bivariate analysis was performed using the Spearman correlation test to evaluate the relationship between the two variables, with a significance level set at p < 0.05. The findings indicated that most participants presented with proteinuria levels of 2+ and 3+, along with elevated leukocyte counts (>10,000/mm³). However, no statistically significant correlation was found between the degree of proteinuria and leukocyte count (p = 0.241 ; p > 0.05). In conclusion, although both proteinuria and leukocyte levels are commonly elevated in cases of severe preeclampsia, their direct association could not be clearly established.

References

[1] Muhammad Fahmi Aminuddin, Amelia Soda, and Maya Tamara Mawardani. “Gambaran Jumlah dan Jenis Leukosit pada pasien Rumah Sakit Umum Daerah Abdul Wahab Sjahranie Samarinda Overview of the Number and Type of Leukocytes in patients of Abdul Wahab Sjahranie Samarinda Regional General Hospital.” Jurnal Teknologi Laboratorium Medik Borneo, 2025, 47–52.

[2] Devita Rahmayani Basuki Rachmad, Apriani. “Deteksi Pre-Eklampsia Pada Ibu Hamil Trisemester 203 Melakui Pemeriksaan Protein Urin.” Jurnal analis kesehatan klinikal sains, 2021, 150–58.

[3] Lyndsey S Benson, Jordan Stevens, Elizabeth A Micks, and Sarah W Prager. “Leukocytosis during cervical preparation with osmotic dilators for dilation and evacuation.” SAGE Open Medicine SAGE, 2021.

[4] Halenur Bozda, Ergül Demirçivi Bör, and Esra Akdeniz. “The predictive value of total leukocyte count and leukocyte differential for severe preeclampsia.” Perinatal Journal, 2018.

[5] Mahesh Chandra and Ansar Ahmad Paray. “Natural Physiological Changes During Pregnancy.” Jounral of biology and medicine, 2024, 85–92.

[6] Murni Lestari Eka Mardiana, Siti Mardhatillah Musa. “Metode Hypnosis Dalam Mengatasi Perubahan Psikologis Selama Masa Kehamilan : Studi Literatur Eka.” 2022.

[7] Jeovan Fillandro, Dewanta Setyawan, Ida Ayu, Dewi Wiryanthini, and Ni Wayan Tianing. “GAMBARAN KADAR PROTEIN URINE PADA IBU HAMIL PREEKLAMPSIA Program Studi Sarjana Kedokteran dan Profesi Dokter , Fakultas Kedokteran Universitas Udayana Departemen Biokimia , Program Studi Sarjana Kedokteran dan Profesi Dokter , Fakultas Kedokteran Universi.” Jurnal Medika Udayana, 2019, 1–5.

[8] Farida Giyartika and Soedjajadi Keman. “PERBEDAAN PENINGKATAN LEUKOSIT PADA RADIOGRAFER DI RUMAH SAKIT ISLAM JEMURSARI.” Jurnal Kesehatan Lingkungan, 2020.

[9] Ria Gustrini. “CALCIUM SUPPLEMENTATION IN PREGNANT WOMEN TO REDUCE Ria Gustirini Program Studi DIII Kebidanan STIKes Muhammdiyah Palembang PENDAHULUAN Preeklampsia adalah gangguan multisistem yang mempersulit 3 % -8 % dari kehamilan dan merupakan salah satu penyebab uta.” Jurnal Kebidanan, 2019, 151–60.

[10] Rumaissa Haidar, Abdeldaem Mohamed, Nahla Mohamed, et al. “Biomarkers of Inflammation and Their Association With the Severity and Onset of Preeclampsia : A Systematic Review.” 2025.

[11] Lulu N. Jumaydha, Youla A. Assa, and Yanti M. Mewo. “Gambaran kadar protein dalam urin pada pekerja bangunan.” Jurnal e-Biomedik, 2016.

[12] Profil Kesehatan Kemenkes. Profil kesehatan indonesia. 2021.

[13] Profil Kesehatan Kemenkes. PROFIL KESEHATAN INDONESIA 2023. 2023.

[14] Elisa Longhitano, Vincenzo Calabrese, Chiara Casuscelli, et al. “Proteinuria and Progression of Renal Damage : The Main Pathogenetic Mechanisms and Pharmacological Approach.” Journal Medicina, 2024.

[15] Nur Masruroh, Lailatul Khusnul Rizki, Uliyatul Laili, and Dhifa Nur Alifah. “The effectiveness of CRP and leukocyte examinations as a detection of risk factors for pre-eclampsia in pregnant women.” 2023, 1227–30.

[16] Jhonatan R Mejia, Jose Ernesto Fernandez-chinguel, Gandy Dolores-maldonado, Jessica Hanae Zafra-tanaka, and Alvaro Taype-rondan. “Heliyon Diagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria : A systematic review and meta-analysis.” Journal Heliyon, 2021.

[17] Rayan Abdelraheem Mohamed and Ibrahim Abdelrhim Ali. “Role of neutrophil / lymphocyte ratio , uric acid / albumin ratio and uric acid / creatinine ratio as predictors to severity of preeclampsia.” BMC Pregnancy and Childbirth, 2023, 1–8.

[18] Nurmainah Nurmainah, Firda M. Hadad, and Mohamad Andrie. “Profil Proteinuria dan Tekanan Darah pada Pasien Preeklampsia Berat yang menggunakan Antihipertensi.” Indonesian Journal of Clinical Pharmacy, 2021, 79.

[19] Tutik Nushah and Yuly Peristiowati. “Analysis of Preeclampsia in Pregnant Women Reviewing from Vascular Disorders due to Endothelial Dysfunction.” Jurnal Ilmiah Kesehatan, 2022, 95–108.

[20] Chinedu L Olisa, Betrand O Nwosu, George U Eleje, et al. “Comparison of urine protein – creatinine ratio and urine dipstick test for significant proteinuria in preeclamptic women.” 2024, 1–12.

[21] Megan A Opichka, Matthew W Rappelt, David D Gutterman, Justin L Grobe, and Jennifer J Mcintosh. “Vascular Dysfunction in Preeclampsia.” Jounal Cells, 2021.

[22] Vebianti Permadi and Pudji Lestari. “Profile of pregnant women with preeclampsia and its termination method.” Jounal unair, 2022, 10–16.

[23] Andreas Putro, Ragil Santoso, Millatul Laila, et al. “HUBUNGAN LEUKOSIT DENGAN PROTEIN URINE PADA IBU HAMIL TRIMESTER III DI PUSKESMAS KLAMPIS BANGKALAN MADURA.” Medical Technology and Public Health Journal (MTPH, 2019, 101–6.

[24] Nadyah Haruna St. Rihlatun Namira Sudirman, Azizah Nurdin, Risma Irnawati, and A Qadir Gassing. “Hubungan Profil Hematologi, Protein Urin, Dan Obesitas Ibu Hamil Pada Kejadian Preeklampsia.” Jurnal Kesehatan, 2024, 238–52.

[25] Magda Rybak-krzyszkowska, Jakub Staniczek, Adrianna Kondracka, et al. “From Biomarkers to the Molecular Mechanism of Preeclampsia — A Comprehensive Literature Review.” International Journal of Molecular Sciences, 2023.

[26] Soufni Morawati dan Helwi Nofira. “Preeklampsia Berat.” Nusantara Hasana Journal, 2025, 318–24.

[27] Lanjing Tang, Nannan Cai, Yao Zhou, Yi Liu, and Jingxia Hu. “Acute stress induces an in fl ammation dominated by innate immunity represented by neutrophils in mice.” Frontiers in Immunology, 2022, 1–13.

[28] Sergio Terracina, Antonio Pallaria, Marco Lucarelli, et al. “Urine Dipstick Analysis on Automated Platforms : Is a Reliable Screening Tool for Proteinuria ? An Experience from Umberto I Hospital in Rome.” journal biomedicines, 2023.

[29] Takuji Tomimatsu, Kazuya Mimura, Shinya Matsuzaki, and Masayuki Endo. “Preeclampsia : Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors.” International Journal of Molecular Sciences, 2019, 1–18.

[30] Nora Veri, Lia Lajuna, Cut Mutiah, Halimatussakdiah, and Dewita. “Patofisiologi Preeeklamsia.” Femina: Jurnal Ilmiah Kebidanan, 2024, 283–96.

[31] Victoria Mank; Waqas Azhar; Kevin Brown. “Leukocytosis.” National Center for Biotechnology Information, 2021.

[32] WHO. “Guidelines for Standard.” 2016, 1–22.

[33] WHO. “Pre-eclampsia.” 2023.

[34] Wiwit Indriyani Aslina and Yuni Riska Hadi. “Differences in Hematocrit and Leukocyte Levels in Preeclampsia and Severe Preeclampsia.” Professional Health Journal, 2025, 741–52.