RELATIONSHIP OF COMMORBID DISEASE TO MORTALITY EVENTS IN COVID-19 PATIENTS
DOI:
https://doi.org/10.53625/ijss.v1i2.5046Keywords:
Comorbid Disease, Mortality, Covid-19Abstract
Background: Covid-19 is a disease caused by acute respiratory syndrome due to corona virus 2. Patients with Covid-19 experience symptoms of severe shortness of breath resulting in death. The risk of death for Covid-19 sufferers will be greater if the patient has a history of comorbid diseases such as hypertension, diabetes mellitus, cardiovascular disease or kidney disease.Objective: The purpose of this study was to determine the relationship between comorbid diseases and the incidence of mortality in patients with Covid-19.Method: Research design using descriptive analytic. The research population was all Covid-19 sufferers who were treated at Mojowarno Christian Hospital (RSK) during 2021 totaling 450 sufferers. The research sample was 212 respondents with a sampling technique using systematic random sampling. The data was obtained from the medical records of Covid-19 patients who were treated at the Mojowarno Hospital. Statistical test using chi square and odds ratio with a significance level of P <0.05. Results: The results of the study found that comorbid diabetes mellitus showed a result of P: 0.000, meaning that there was a relationship between comorbid diabetes mellitus and the incidence of mortality in patients with Covid-19. Comorbid kidney disease shows a P value: 0.003, meaning that there is a relationship between comorbid kidney disease and the occurrence of mortality in Covid-19 sufferers. Comorbid heart disease results obtained P: 0.089, meaning that there is no relationship between comorbid heart disease and mortality in patients with Covid-19. Hypertensive comorbid disease on mortality with a P value: 0.134 meaning that there is no relationship between hypertension comorbid disease and the risk of mortality in patients with Covid-19. Conclusion:Covid-19 sufferers who have comorbid diabetes mellitus cause greater mortality. This is because diabetes mellitus can cause a cytokine storm which plays a role in increasing the severity of COVID-19 sufferers so that it often causes death.
References
Clerkin , K. J. , Fried , J. A. , Raikhelkar , J. , Sayer , G. , Griffin , J. M. , Masoumi , A. , Jain , S. S. , Burkhoff , D. , Kumaraiah , D. , Rabbani , L. R. , Schwartz , A. , . & Uriel , N. ( 2020 ). COVID 19 and Cardiovascular Disease.Circulation, 1648–1655.
https://doi.org/10.1161/CIRCULATIONAHA.120.046941
Gansevoort, R. T., & Hilbrands, L. B. (2020). CKD is a key risk factor for COVID-19 mortality. Nature Reviews. Nephrology, 16(12), 705–706. https://doi.org/10.1038/S41581-020-00349-4
Fang, L.; Karakiulakis, G., & Roth, M. 2020. Are Patients with Hypertension and Diabetes Mellitus at Increased Risk for COVID-19 Infection. The Lancet Respiratory Medicine, (4): e21
Gansevoort, R. T., & Hilbrands, L. B. 2020. CKD is a key risk factor for Cvid-19 mortality. Nature Reviews. Nephrology, 16(12), 705–706. https://doi.org/10.1038/S41581-020- 00349-4
Guan W, Ni Z, Hu Y, Liang W, Ou C, He J. et al. 2020. Clinical Characteristics of Coronavirus Disease 2019 in China.N Engl J Med.2020;382(18):1708–20.
Drew, Clement, and Asri C Adisasmita. 2021.Symptoms and Comorbidities Affecting Mortality of Positive COVID-19 Patients in East Jakarta, March-September 2020. 3(3): 274–83.
Hidayani, W. R. (2020). Risk Factors Associated With Covid 19: Literature Review.Journal for Healthy Society(JUKMAS), 4(2), 120-134.
Ministry of Health, Republic of Indonesia. (2020). Guidelines for Prevention and Control of Corona Virus Disease (Covid-19). 1–214.https://Doi.Org/10.33654/Math.V4i0.299 Kreutz, R., Algharably, E. A. E. H., Azizi, M.,
Mentari, Princess Shawwa. 2021.Overview of Clinical Characteristics and Comorbid Diseases
Sufferers of Coronavirus Disease (Covid-19) at RSUP Dr. Wahidin Sudirohusodo.
Parveen R., N. Sehar, R. Bajpai and N. B. Agarwal. 2020. Association ofdiabetes and hypertension withdisease severity in covid-19patients: A systematic literaturereview and exploratory metaanalysis. Diabetes Research and Clinical Practice, vol. 166, no.108295, pp. 1-8, 2020
Satria, R., Tutupoho, R., & Chalidyanto, D. 2020. Analysis of Death Risk Factors with Covid-19 Comorbid Diseases.Silampari Journal of Nursing, 4(1), 48-55.https://doi.org/https://doi.org/10.31539/jks.v4i1.1587
Shereen, M. A., Khan, S., Kazmi, A., Bashir, N., & Siddique, R. 2020. Covid-19 infection: Emergence, transmission, and characteristics of human coronaviruses. Journal of advanced research, 24, 91-98.
Suganthan, N., (2019).Review Article. Jaffna Medical Journal, 31 (2), hal.5-6 (https://jmj.sljol.info/articles/abstract/10.4038/jmj.v31i2.72/)
Trisnawati. 2013. Risk Factors for Type 2 Diabetes Mellitus at the Cengkareng District Health Center, West Jakarta,Scientific Journal of Health Vol.5, No.1, http://lp3m.thamrin.ac.id/upload/artikel%202.%20vol%205%20no%201_shara.pdf,accessed on 20 June 2022.
Wu, JT.; Leung, K.; Bushman, M.; Kishore, N.; Niehus, R.; De Salazar, PM.; Cowling, BJ.; Lipsitch, M L. G. (2020). Estimating Clinical Severity Of COVID-19 From The Transmission Dynamics In Wuhan, China. Night With.Https://Doi.Org/10.1038/S41591- 020-0822-7.
WHO.2020a. Coronavirus disease 2019 (COVID-19) Situation Report - 43. 03 March 2020. Available from URL: https://www.who.int/docs/default-source/coronaviruse/situation reports/20200303-sitrep-43-covid-19.pdf?sfvrsn=2c21c09c_2 (accessed March 2021).
WHO. 2020b. Coronavirus disease 2019 (COVID-19) situation report–107 https://www.who.int/docs/default-source/coronaviruse/situation
reports/20200506covid-19-sitrep-107.pdf?sfvrsn=159c3dc_2 (May 6, 2020), Accessed May 2021
Willim, H. A., Ketaren, I., & Supit, A. I. 2020. Impact of Coronavirus Disease 2019 on the Cardiovascular System.E-CliniC, 8(2). https://doi.org/10.35790/ECL.V8I2.30540
Zhang, J., Wu, J., Sun, X., Xue, H., Shao, J., Cai, W., Jing, Y., Yue, M., & Dong, C. 2020. Association of hypertension with the severity and fatality of SARS-CoV-2 infection: A meta-analysis. Epidemiology & Infection, 148, e106. https://doi.org/10.1017/S095026882000117X
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